Palmitic acid, a saturated fat concentrated in meat and dairy products, can increase the likelihood of cancer cells metastatic via the fat receptor CD36.
The main cause of death in cancer patients is metastasis formation. That’s how most people die from cancer rather than from primary tumors, but cancer spreads within the body. “It is estimated that metastasis is responsible for about 90% of cancer deaths,” says little advances in stopping spreads despite modern medical armor. In fact, it can make the problem worse. In an editorial entitled “Treatment-induced metastasis,” the authors “providing evidence that all common treatments, including radiation therapy, chemotherapy, fine needle biopsy, surgical procedures, and anesthesia, can contribute to tumor progression.” Why can amputation around the tumor and cutting blood vessels lead to “transfer of residual tumor cells”? But why chemotherapy? How does chemotherapy worsen metastasis? “Even though we reduce the size of the primary tumor, chemotherapy changes the tumor microenvironment” (surrounding tissue) “increases the escape of cancer cells into the bloodstream.” Sometimes chemotherapy, surgery, and radiation are completely justified, but again these treatments can make things worse. If there is a way to treat the cause of cancer spread.
The development of anti-metatic therapy is hampered by the fact that cells that initiate the metastasis remain unidentified. Next, a landmark study “targeting metastasis-initiated cells via the fatty acid receptor CD36” was published. Researchers have found that subpopulations of human cancer cells are “unique in their ability to initiate metastasis.” They all express high levels of fat receptors known as CD36, known as “fat controllers.” Palmitic acid or high-fat diets are found to particularly increase the metastatic potential of these cancer cells. Where is palmitic acid? Originally discovered in palm oil, palmitic acid is the most concentrated in meat and dairy products. “New evidence shows that palmitate (PA), a common fatty acid in the human diet, functions as a signaling molecule that regulates the progression and development of many diseases at the molecular level.” We find that saturated fats are recognized by the CD36 receptors in cancer cells, and that if the CD36 receptor is blocked, it is responsible for metastasis as well.
This study was human cancer, but it was human cancer implanted in mice. However, clinically (meaning cancer patients themselves), the presence of metastasis-initiated cells with these CD36 supplemented actually correlates with poor prognosis. For example, CD36 appears to promote brain tumor progression. As seen in the survival curves shown below, in my video, what causes cancer metastasis? The same applies to breast cancer mortality rates. “In this study, we correlated mortality in breast cancer patients with tumor CD36 expression levels.” “It is not surprising because CD36 plays an important role in proliferation, migration, and… breast cancer cell growth. Inhibition of CD36 can inhibit “breast cancer cell migration and invasion.”
Under me and at 3:46 videoyou can look Migration and invasion of breast cancer cells before and after CD36 inhibition. (The upper line with the circle is in front of CD36 inhibition, and the final line with the square is in after.)
This is not just about “tumors derived from human melanoma and breast cancer.” By blocking CD36, it is also believed that “CD36 expression promotes ovarian cancer progression and metastasis.” The same type of effect can also be seen in prostate cancer. It suppresses fat intake by prostate cancer cells and suppresses tumors. However, all of this was studied with receptor blocking agents and antibodies in laboratory settings. If these “metastatic cancer cells rely on dietary lipids (fats) to promote the spread of cancer, especially when it comes to promoting the spread of cancer, wouldn’t they just block dietary fats?
“Lipid metabolism promotes cancer spread.” Cancer cells love fat and cholesterol. The reason is that so much energy is stored in fat. “Therefore, CD36+ metastatic cells may take advantage of this feature to obtain the large amount of energy needed to fix and survive at sites away from the primary tumor” – to set up stores throughout the body.
“We’re over the days when glucose (sugar) was considered the main fuel, if not just fuel to support cancer cell growth.” It appears there is a “fatty way to metastasize.” It is no wonder that high-fat diets (HFDs) “may play an important role in increasing the risk of different cancer types, and many clinical studies have linked HFD to several advanced cancers.”
If dietary fats are “oiling the wheels of a cancer machine,” is there a “specific diet” that can be used to starve cancer with dietary fat? You don’t know until you put it in the test.
